Lead Sponsor

Circassia Limited

Collaborators

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Male or female, aged 18-65 years.
•Asthma treated by inhaled SABA or inhaled SABA plus low-medium dose ICS in 6 weeks prior to randomisation.
•A reliable history consistent with moderate to severe rhinoconjunctivitis on exposure to grass for at least the previous two grass seasons.
•Positive skin prick test to grass.
•Grass-specific Immunoglobulin E (IgE) ≥ 0.35 kU/L.

•History of life-threatening asthma.
•Uncontrolled asthma according to GINA.
•FEV1 of \<70 % of predicted, regardless of the cause.
•Administration of adrenaline (epinephrine) is contraindicated (e.g. subjects with acute or chronic symptomatic coronary heart disease).
•History of severe drug allergy or anaphylactic reaction to food.
•A history of any significant disease or disorder (e.g. immune system, pulmonary, cardiovascular, gastrointestinal, liver, renal, neurological, metabolic, malignant, psychiatric, major physical impairment, history of alcohol or drug abuse)