Lead Sponsor

Infraredx

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•≥18 years of age
•Scheduled for a coronary angiogram at the Royal Adelaide Hospital.
•Women must be non-lactating or not of childbearing potential (1 year post menopausal or surgically sterilized \[total hysterectomy, bilateral tubal ligation, bilateral oophorectomy\]).
•Target artery must be \>2 mm to accommodate the IVUS catheter.
•IVUS must be clinically indicated or indeterminate angiographic lesion in the artery (40%-70% angiographic stenosis)

•Cardiogenic shock
•Contraindications to intracoronary nitroglycerin (hypertrophic obstructive cardiomyopathy; cerebral hemorrhage, head trauma; concomitant sildenafil, tadalafil or vardenafil use)
•Known coronary artery spasm
•Significant bleeding risk (i.e. previous hemorrhagic stroke, active peptic ulcer disease)
•Bleeding diathesis
•Significant renal impairment (patients will be excluded if their calculated creatinine clearance is \< 30 mL/min)