Age

18–60

Sex

ALL

Healthy volunteers

Not accepted

Patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) or primary progressive multiple sclerosis (PPMS) fulfilling the McDonald criteria
Expandend Disability Status Scale (EDSS) 3-6.5
Pyramidal Functional Score ≥ 2
Participants must be able to transport self to gym and to the University of Southern Denmark
Participants must be able to complete T25FW and SSST
Fertile female participants are obliged to use hormonal contraceptive measures

History of epileptic seizures
MS relapse or change in disease modifying treatment (DMT) within 60 days
Cancer within five years
Blood pressure ≥ 160/100
Severe arrhythmia or ischaemic heart disease or unexplained abnormal cardiac auscultation
≥ ALT 90 U/l, ≥ BSP 210 U/l, ≥ γ-GT 230 U/l
GFR \< 80 ml/min.
History of severe pulmonary disease or unexplained abnormal pulmonary auscultation
Pregnancy
Breastfeeding
Allergy to substances contained in prolonged release Fampridine tablets
Concomitant treatment with carvedilol, propranolol or metformin.

Resistance Training and Amino Pyridine in Multiple Sclerosis