ADAM17 Inhibitor/ Rituximab After Auto HCT for DLBCL

Inclusion Criteria

• •Patients 18 years or older who have undergone an autologous HCT for the treatment of DLBCL and are in a complete remission (CR), partial remission (PR) or have stable disease (SD) at the day 28 post-transplant reassessment
• •Karnofsky Score of ≥ 70% (appendix II)
• •Able to start the protocol therapy (1st dose of rituximab) between day 28-75 post-transplant
• •Adequate organ function defined as:
• •* Hematologic: platelets ≥ 50,000 x 109/L; ANC ≥ 1000 x 109/L unsupported by G-CSF or GM-CSF for 3 days
• •* Renal: creatinine \< 1.5 mg/dl or glomerular filtration rate \> 50 ml/min
• •* Pulmonary: clinically no evidence of pulmonary disease
• •* Cardiac: no symptoms of uncontrolled cardiac disease
• •If post-transplant consolidation radiation therapy is given, the patient must be at least 14 days between last radiation treatment and 1st dose of rituximab
• •Able to take daily aspirin (325 mg) for the duration of INCB7839 treatment and 1 week after the last dose to reduce the risk of thrombosis (not applicable if on other anti-coagulant therapy at time of study enrollment)
• •Females are either postmenopausal for at least 1 year, are surgically sterile for at least 3 months, or must agree to take appropriate precautions to avoid pregnancy (with at least 99% certainty) from screening through 12 months after the last dose of rituximab if of childbearing potential. (Note: Permitted methods that are at least 99% effective in preventing pregnancy should be communicated to the participants and their understanding confirmed).
• •Males must agree to take appropriate precautions to avoid fathering a child (with at least 99% certainty) from screening through 12 months after the last dose of rituximab. (Note: Permitted methods that are at least 99% effective in preventing pregnancy should be communicated to the participants and their understanding confirmed).
• •Voluntary written consent signed before performance of any study-related procedure not part of normal medical care