Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

Inclusion Criteria

• •Gestational age: 16 weeks, 0 days to 26 weeks, 0 days.
• •Confirmed TTTS patients, who by definition meet the following sonographic criteria:
• •* Single placenta.
• •* Polyhydramnios: maximum vertical pocket ≥ 8 cm in the recipient twin, prior to amniodrainage.
• •* Oligohydramnios: maximum vertical pocket ≤ 2 cm in the donor twin, prior to amniodrainage.
• •* Thin dividing membrane (absence of twin peak sign) or absence of dividing membrane (monoamniotic).
• •* Same gender, if visible.
• •* Quintero Stages 1-4.
• •Patients choosing laser therapy that have undergone prior therapeutic amniocentesis may be included.
• •Patients with an anterior placenta may be included.
• •Triplet gestations with two or three fetuses sharing the same placenta may be included.
• •Patients must be able to give written informed consent.