Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

AMP Up aims to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition into adulthood. A group of uninfected perinatally-exposed young adults from a similar sociodemographic background and age distribution will be enrolled for comparison. The primary objectives of this study are: * To identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART, including disease progression, immune dysfunction, viral resistance, end-organ disease, and mortality. * To define the impact of HIV infection and ART on the long-term clinical outcomes of young adults, including: * Metabolic abnormalities and risk factors for cardiovascular disease, including glucose and lipid metabolism, blood pressure, and body composition. * Sexually transmitted infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, syphilis, human papillomavirus (HPV), genital warts and HSV) among males and females, and cervical HPV-associated pre-cancers and cancers and Mycoplasma genitalium and other vaginal microbiota among females. * Reproductive health, fertility, and pregnancy outcomes including mother-to-child transmission of HIV. * To define the impact of perinatal HIV infection, its concomitant risk factors and ART on long-term neurocognitive and behavioral health outcomes, including: * Mental health and neurocognitive functioning. * Health care behaviors, including adherence to ART, participation in health care services, and transition to adult clinical care. * Risk behaviors, including sexual behavior and substance use. * Independent living skills, and vocational and education achievement necessary for successful transition to adult functioning and quality of life.