Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging

Exclusion Criteria

• •1. FEV1 and/or TLC \< 70% predicted.
• •2. Inability to perform the study (by primary MD or investigator assessment).
• •3. Inability to perform the respiratory maneuvers necessary for the exam.
• •4. Subjects who have a past or present disease, which as judged by the Investigators may affect the outcome of this study.
• •5. The subject has suspected history of drugs or alcohol abuse within the six months prior to the screening visit.
• •6. The subject is a woman of childbearing potential who is pregnant, seeking to become pregnant, or has a positive pregnancy test.
• •7. Subject with clinical instability in the judgment of the investigator, with a heart rate \> 120 bpm, respiratory rate \> 24, SpO2 \< 88%, blood pressure \< 90/60 or \> 140/90 or fever \> 101, or subjects with hospitalization for progression of pulmonary hypertension or right heart failure in the three months prior to the study.
• •8. Subject with diagnosis of active tuberculosis, lung cancer, clinically overt bronchiectasis, allergic rhinitis, asthma, heart failure, ischemic heart disease, or COPD.
• •9. Subject that had a respiratory tract infection in the 4 weeks prior to the screening visit and throughout the duration of the study.
• •10. The subject has been exposed to a radiation dose over the past year that, when added to the radiation dose expected in this study, would exceed permissible yearly exposure as determined by the MGH radiation safety committee.