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COMPLETEDPhase 2NCT02104011

Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers

Treatment of angiomyolipomas is based on invasive techniques such as surgery or embolization. Development of anti-angiogenic therapies is a major and growing field of research in hypervascularized tum...

Lead sponsor: University Hospital, Bordeaux•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University Hospital, Bordeaux

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Tuberous sclerosis patients with one or several angiomyolipomas of a size of at least 4 cms.

Exclusion Criteria

•Patients whom CT or MR scan shows one or several intra-lesional aneurisms requiring a preventive embolization.
•Patients with a retroperitoneal hemorragic complication requiring a preventive embolization.
•Patients whom biopsy will show an adenocarcinoma, hypertension non controlled, renal failure and severe liver.
•Diabetic subjects insufficiently controlled.
•Beta-blockers contra-indication.
•Psychosis, severe mental disorder.
•Patient already treated with beta-blockers or mTOR inhibitors.
•Pregnant or nursing women.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 23, 2018Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment2

Start dateMay 2015

Last updatedJan 23, 2018

Condition

Renal Angiomyolipomas Tuberous Sclerosis

Locations shown

Nephrology department

Bordeaux

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 23, 2018Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions