Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obstructive Pulmonary Disease and Very Severe Steady State

Exclusion Criteria

• •Patient under nebulizer or has been treated with nebulized bronchodilators at home over the last 6 months
• •Patient with an indication of oxygen is expected in the coming year
• •Progressive malignant disease known
• •Patient under non-invasive ventilation (NIV) for less than 6 months or NIV provided in the following year
• •Patient known to be colonized by Pseudomonas aeruginosa, A. xylosoxidans, Burkholderia cepacia or Stenotrophomonas maltophilia
• •Patients with severe cardiovascular disease
• •Pregnancy