Pharmacokinetics of MP-3180 in Healthy Volunteers

Exclusion Criteria

• •1\. Institutionalized participants will not be used
• •2\. Social habits:
• •* a. Ingestion of any alcoholic, caffeine- or xanthine-containing food or beverage within the 48 hours prior to the initial dose of study medication.
• •* b. Ingestion of any vitamins or herbal supplement within 7 day prior to the initial dose of study medication.
• •* c. Any significant change in dietary or exercise habits within the 48 hours prior to the initial dose of study medication.
• •* d. History of drug and/or alcohol abuse within the past year, unless currently enrolled in an abstinence program.
• •3\. Use of any prescription or over-the-counter (OTC) medications within the 7 days prior to the initial dose of study medication.
• •4\. History of any significant cardiovascular disease, renal, pulmonary, hematologic, endocrine, immunologic, dermatologic, neurologic (including any history of seizure disorder), psychological, musculoskeletal disease or malignancies unless deemed not clinically significant by the Principal Investigator or Medical Sub-Investigator.
• •5\. Acute illness at the time of either the pre-study medical evaluation or dosing.
• •6\. Not within normal limits or clinically significant for lab testing
• •7\. Any reason which, in the opinion of the Principal Investigator or Medical Sub-Investigator, would prevent the participant from safely participating in the study.
• •8\. Donation or loss of blood or plasma: 50 mL to 499 mL within 30 days prior to the initial dose of the study medication; or more than 499 mL within 56 days prior to the initial dose of study medication.
• •9\. Intolerance to venipuncture.
• •10\. Participants who have received an investigational drug within 30 days prior to the initial dose of study medication.
• •11\. History of allergy or hypersensitivity to MP-3180 or iohexol, or other related products, or any of the inactive ingredients.
• •12\. Any food allergy, intolerance, restriction or special diet that, in the opinion of the Principal Investigator or Medical Sub-Investigator, could contraindicate the participant's participation in this study.
• •13\. History of allergy or hypersensitivity to iodine containing contrast media or drugs.