Afatinib in Subjects With Kidney Dysfunction

Exclusion Criteria

• •Any finding of the medical examination (including Blood Pressure (BP), Pulse Rate (PR) and Electrocardiogram (ECG)) deviating from normal and of clinical relevance, e.g. repeated measurement of systolic blood pressure \< 90 mmHg (millimeter of mercury) or \> 140 mmHg, diastolic blood pressure \< 50 mmHg or \> 90 mmHg, repeated measurement of pulse rate \< 45 bpm (beats per minute) or \> 90 bpm.
• •Any evidence of a clinically relevant concomitant disease.
• •Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological, dermatological or hormonal disorders.
• •Relevant gastrointestinal tract surgery (except appendectomy).
• •Diseases of the central nervous system (such as epilepsy, seizures) or psychiatric disorders or neurological disorders.
• •History of photosensitivity or recurrent rash.
• •Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders.