Safety and Efficacy of Romidepsin and the Therapeutic Vaccine Vacc-4x for Reduction of the Latent HIV-1 Reservoir

Exclusion Criteria

• •1. CD4 T cell count nadir \<200 cells/mm3
• •2. Previous treatment with an HDACi (Histone deacetylase inhibitor) within the previous 6 months
• •3. Any evidence of an active AIDS-defining opportunistic infection, active HBV or HCV co-infection, significant cardiac disease, malignancy, transplantation, insulin dependent diabetes mellitus or other protocol defined excluded medical condition
• •4. Use of any protocol defined contraindicated medication or vaccination
• •5. Unacceptable values of the hematologic and clinical chemistry parameters as defined in the protocol.
• •6. Males or females who are unwilling or unable to use protocol defined methods of contraception