Pilot Study Exploring the Use of Hyperbaric Oxygen in Autologous Peripheral Blood Stem Cell Transplantation

Inclusion Criteria

• •Voluntary written informed consent
• •Subjects with Multiple Myeloma (MM), Hodgkin's Disease (HD), and non-Hodgkins lymphoma (NHL) who are eligible for high-dose chemotherapy and autologous PBSC transplant. Subjects should be enrolled within 30 days of transplant.
• •Subjects must be \>/= 18 yrs old and \</= 70 yrs old
• •Karnofsky performance status of \>/= 70%
• •Adequate hepatic, renal, cardiac and pulmonary function to be eligible for transplant. Minimum criteria include:
• •* ALT (alanine aminotransferase), AST (aspartate aminotransferase): \< 4x IULN (institutional upper limit of normal)
• •* Total bilirubin: \</= 2.0 mg/dL
• •* Creatinine: \</= 2.0 mg/dL
• •* EF (ejection fraction) measured by 2D-ECHO or MUGA (multiple gated acquisition) scan of \>/= 45%
• •* FEV1 (forced expiratory volume), FVC (forced vital capacity) and DLCD(diffusing capacity of lung for carbon monoxide) \>/= 50% of predicted value (corrected to serum hemoglobin)
• •Women of child-bearing potential and men with partners of child-bearing potential must use adequate contraception prior to study entry and up to 30 days following treatment.