Obese/lean individuals

Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, congestive heart failure, cardiac shunts, cardiac surgery, pulmonary hypertension, cardiac arrhythmias, family history of cardiac arrhythmias or sudden cardiac death)

Diabetes mellitus/impaired glucose metabolism (fasting glucose values \> 5.6 mmol/L

Stage 3 hypertension (blood pressure \> 180/110 mm Hg)

Unstable or severe pulmonary disease

Unstable or severe thyroid disorders

Inflammatory diseases

Smoking

Alcohol use \> 2 U/day (women)/\> 3 U/day (men)

Use of antihypertensive, lipid-lowering or glucose-lowering medications

Use of corticosteroids and regular use of NSAIDs

eGFR\< 60 mL/min

Impairment of hepatic function

Pregnancy or lactation

Aldosterone, Microvascular Function and Salt-sensitivity

What this study is about