Clinical diagnosis of schizophrenia or schizoaffective disorder (DSM-IV-TR);
Ages between 18 and 55 years old, both genders;
Must be using adequate contraception if a fertile woman;
Must be on clozapine treatment for at least 6 months, with or without augmenting strategies;
Must be clozapine-resistent (super-refractory patient), defined by a CGI-severity ≥ 4, PANSS total score ≥ 60 and at least 4 items of the positive subscale ≥ 4 at baseline.
You may not be if
Clinical somatic disease not stabilized in the three months preceding the study;
Other Axis I disorders (DSM-IV-TR);
Laboratory tests with significantly abnormal values that persist for more than two weeks;
Lack of permanent residence during the study period;
History of poor treatment adherence.
History of ECT use in the past six months that precede the start of the study.
