A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)

Exclusion Criteria

• •1. hospitalization for acute heart failure decompensation
• •2. cardiogenic shock (Systolic Blood Pressure \< 80mmHg)
• •3. Need or plan for renal replacement therapy (dialysis, kidney transplant)
• •4. serum creatine level \> 2.5mg/dl
• •5. serum potassium (K+) \> 5.5mg/dl
• •6. Age \> 80 years old or poor compliance patients
• •7. allergy, adverse drug reaction, hypersensitivity to any kinds of diuretics
• •8. life expectancy \< 6 months (e.g. metastatic malignancy, liver cirrhosis)
• •9. pregnancy or women at age of childbearing potential