TMI With HD Mel in ASCT for R/R Multiple Myeloma (BMT-03)

Inclusion Criteria

• •1. Patients meeting criteria for symptomatic myeloma
• •2. Patients who have progressive myeloma following initial induction (patients may have received any number of treatment regimens including prior autologous transplant)
• •3. Patient age 18-75 years at time of enrollment
• •4. Karnofsky performance status of ≥70
• •5. Cardiac function: LVEF \>40%
• •6. Hepatic: Bilirubin \<2x upper limit of normal and ALT and AST \< 2.5x the upper limit of normal
• •7. Renal: Creatinine clearance of \>30mL/min, estimated or calculated
• •8. Pulmonary: DLCO, FEV1, FVC \>50% of predicted (after correction for hemoglobin)