Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SPARC1316

Exclusion Criteria

• •Subjects with a supine systolic blood pressure ≥160 mmHg and/or a supine diastolic blood pressure ≥100 mmHg
• •Subjects who have a significant infection or known inflammatory process on screening or admission.
• •Subjects who are unlikely to co-operate with the requirements of the study.
• •Positive serology for infectious disease (hepatitisB or C , HIV) at screening