A 28-Day Parallel Group Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria

• •Subject is a male or female subject 40 years of age or older
• •Subject must have a negative pregnancy test, and must be prepared to use effective contraception if of child-bearing potential
• •Subject is capable of performing reproducible spirometry maneuvers
• •Subject has post-bronchodilator FEV1/FVC ratio \<0.7
• •Subject has moderate-to-severe stable COPD (Stage 2 or 3 according to the GOLD Guidelines)
• •Subject has a post-bronchodilator FEV1 greater than or equal to 30% and less than 80% of predicted normal
• •Subject has a current or past smoking history of at least 10 pack-years.