Severe head trauma where therapeutic coma is indicated

Therapeutic hypothermia where therapeutic coma is indicated

Status epilepticus where therapeutic coma is indicated

Patient has participated in the study before

Patient is transferred from another ICU with length of stay \> 48 hours

Patient is comatose at admission

PaO2/FiO2 ≤ 9, if sedation is necessary for oxygenation

Patient does not speak Danish, swedish or norwegian at a reasonable level

Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD