Any current pharmacological treatment for hypertension, including diuretics (calcium channel blockers at stable doses were later allowed)

Estimated glomerular filtration rate \< 60 mL/min/1.73m2

Current use of any urate-lowering therapy or statins

Prior diagnosis of gout or past use of urate-lowering therapy for gout

Prior diagnosis of diabetes

Pregnancy, or recent delivery or last trimester pregnancy loss more recent than 3 months

Active smokers

Immune-suppressed individuals including transplant recipients or current use of azathioprine.

Leucopenia with absolute white cell count \< 3000 /mL, anemia with hemoglobin \< 12 g/dL, or thrombocytopenia with platelet count \< 150,000/mL

Individuals of Han Chinese or Thai descent with HLAB5801 genetic phenotype

Serious medical condition that at investigator's judgment precludes utilization of a fixed dose of allopurinol

Center of Research Translation (CORT) Project 2