Duration of ANtibiotic Therapy for CEllulitis

Exclusion Criteria

• •Allergy for flucloxacillin, other beta-lactam antibiotics or one of the additives, or flucloxacillin induced hepatitis or liver enzyme disorders.
• •Concurrent use of antibiotics for other indications
• •Alternative diagnosis accounting for the clinical presentation.
• •All cases involving any of the following complicating factors:
• •* Use of antibiotics with Gram-positive activity for more than 4 days in the past 7 days
• •* Intensive care unit admission during the last 7 days
• •* Severe peripheral arterial disease (Fontaine IV)
• •* Severe cellulitis necessitating surgical debridement or fascial biopsy
• •* Necrotizing fasciitis
• •* Periorbital or perirectal involvement
• •* Surgery
• •* Life expectancy less than one month
• •* Risk factors associated with Gram-negative pathogens as a causative agent:
• •* Chronic or macerated infra-malleolar ulcers, or infra-malleolar ulcers with previous antibiotic treatment, in patients with diabetes mellitus.
• •* Neutropenia
• •* Cirrhosis (Child-Pugh class B or C)
• •* Intravenous drug use
• •* Human or animal bite
• •* Skin laceration acquired in fresh or salt open water
• •* Fish fin or bone injuries