TNF-alpha Inhibition in CRPS: A Randomized Controlled Trial

Exclusion Criteria

• •1. Active malignancy or history of malignancy.
• •2. Active infection.
• •3. History of Tuberculosis (TB) or TB exposure.
• •4. Pregnancy.
• •5. Concomitant disease causing immunocompromise.
• •6. Concomitant autoimmune disease such as rheumatoid arthritis, psoriasis, ankylosing spondylitis or Crohn's Disease.
• •7. Poorly controlled psychiatric disease including anxiety, depression or attention deficit hyperactivity disorder.
• •8. Hepatic or renal impairment as indicated by serum transaminases and/or creatinine ≥ 150% normal value for age.
• •9. Evidence of or history of demyelinating disease.