Prognostic Value of Tumor Hypoxia, as Measured by 18F-FMISO Breath Hold PET/CT, in Non-Small-Cell-Lung Cancer (NSCLC) Patients

Inclusion Criteria

• •Pathologic confirmation of NSCLC at MSKCC
• •No prior treatment for this diagnosis of NSCLC
• •Patient to be treated with neoadjuvant chemotherapy (35 patients total) or patient to be treated with definitive RT,sequential chemo-RT, or concurrent chemo-RT (minimum dose of 50 Gy in 25 fractions) (25 patients total)
• •Tumor must measure ≥ 2cm on CT
• •Age ≥ 18 years
• •Ability to hold the breath for 10 seconds.
• •Karnofsky performance status ≥ 70%
• •Women of childbearing age must have a negative blood pregnancy test