Carbohydrate Antigen 125-guided Therapy in Heart Failure

Exclusion Criteria

• •Life expectancy \<12 months due to other diseases different from HF.
• •Having undergone a cardiac transplantation, coronary revascularization procedure (percutaneous coronary intervention and/or coronary artery bypass grafting) or cardiac valve replacement in the past 3 months.
• •Angina pectoris higher than class II (Canadian Cardiovascular Society Classification).
• •Pregnancy at the moment of enrollment.
• •Valvular heart disease already scheduled for surgical intervention.
• •Severe chronic obstructive and/or restrictive pulmonary disease, requiring continuous oxygen administration.
• •Serum creatinine level \> 3 mg/dl or chronic renal insufficiency on dialysis treatment.
• •Patients receiving resynchronization therapy during the index admission.
• •Significant concurrent medical diseases including cancer or a history of cancer within 5 years of entering the screening period, endometriosis, cirrhosis, acute coronary syndrome within 6 months, uncontrolled hypertension, history of human immunodeficiency virus (HIV) infection, or a significant active infection.
• •Participating in another randomized study.