Lead Sponsor

National Center of Neurology and Psychiatry, Japan

Age

20 - 65 years

Sex

ALL

Healthy Volunteers

No

•DSM-IV diagnosis of Major Depressive Disorder, Dysthymia, Depressive Disorder Not Otherwise Specified, Panic Disorder With Agoraphobia, Panic Disorder Without Agoraphobia, Agoraphobia Without History of Panic Disorder, Social Phobia(Social Anxiety Disorder), Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Generalized Anxiety Disorder, Anxiety Disorder Not Otherwise Specified assessed by SCID.
•Depressive and anxiety symptoms is mild or more severe (GRID-HAMD \>= 8).
•Ages 20 years or older, and 65 years or younger at screening.
•Subjects who give full consent in the participation of the study.

•No alcohol or substance use disorder in 6 months prior to the screening assessed by SCID
•No current manic episode or current schizophrenia and other psychotic disorders at baseline assessed by SCID
•No serious suicidal ideation at baseline (GRID-HAMD Item3 severity is 3 or higher.)
•No life-threatening, severe or unstable physical disorders or major cognitive deficits at baseline.
•Evidence of unable to participate half or more of the intervention phase.
•No structured psychotherapy during at baseline.
•Other relevant reason decided by the investigators.