Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hospices Civils de Lyon
Age
70–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Woman \>70 year old
Histologically or cytologically proven FIGO stage III to IV epithelial ovarian cancer or peritoneal primary or fallopian tube. A cytological proof is accepted if associated with a ratio of CA125/CEA \>25 and a radiological pelvic mass.
GVS (Geriatric Vulnerability Score) \>3.
Adequate bone marrow function including the following: Neutrophils ≥ 1.5 x 109/L , platelets ≥100 x 109/L and hemoglobin ≥9 g/dL.
Adequate glomerular filtration rate \>40 ml/min (estimates based on MDRD or Chatelut formula are sufficient)
No icterus.
Life expectancy \> 3 months.
Written informed consent obtained.
Covered by a Health System where applicable
You may not be if
Other malignancy within the last 5 years, except for adequately treated carcinoma in situ of the cervix or squamous carcinoma of the skin, or adequately controlled limited basal cell skin cancer.
Prior history of chemotherapy.
Prior history of radiotherapy which may affect patient tolerability to chemotherapy.
Major perturbations of liver biology: Bilirubin \> 2 fold the upper normal limit (UNL), SGOT-SGPT \> 3 fold UNL.
Patient unable to be regularly followed for any reason (geographic, familial, social, psychologic).
Any mental or physical handicap at risk of interfering with the appropriate treatment.
Known allergy to Cremophor ® EL -containing drugs.
Any administrative or legal supervision where applicable
Clareo Health | EWOC-1 Trial: Carboplatin +/- Paclitaxel in Vulnerable Elderly Patients With Stage III-IV Advanced Ovarian Cancer
