Combination Checkpoint Inhibitor Plus Erlotinib or Crizotinib for EGFR or ALK Mutated Stage IV Non-small Cell Lung Cancer

Exclusion Criteria

• •Concurrent therapy with any other non-protocol anti-cancer therapy.
• •History of any other malignancy requiring active treatment.
• •Patients who have had a history of acute diverticulitis, intra-abdominal abscess, Gastrointestical obstruction and abdominal carcinomatosis which are known risk factors for bowel perforation.
• •History of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis \[scleroderma\], systemic lupus erythematosus, autoimmune vasculitis \[e.g., Wegener's Granulomatosis\]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre Syndrome). History of vitiligo and adequately controlled endocrine deficiencies such as hypothyroidism are allowed.
• •Significant cardiovascular disease including:
• •Active, clinically symptomatic left ventricular failure.
• •Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive agents.
• •Myocardial infarction, severe angina, or unstable angina within 6 months prior to administration of first dose of study drug.
• •History of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation)
• •Cardiac arrhythmias requiring anti-arrhythmic medications (except for atrial fibrillation that is well controlled with anti-arrhythmic medication)
• •Coronary or peripheral artery bypass graft within 6 months of screening.
• •Uncontrolled CNS metastases are not allowed; subjects with previously treated brain metastases will be allowed if the brain metastases have been treated, toxicities have resolved to grade 1 or baseline and steroids are no longer required. Leptomeningeal metastases are not allowed.
• •Serious/active infection or infection requiring parenteral antibiotics.
• •Pregnant or lactating females.
• •HIV infection or chronic hepatitis B or C. Negative Screening tests for HIV, Hepatitis B, and Hepatitis C are required.
• •The presence of any other medical or psychiatric disorder that, in the opinion of the treating physician, would contraindicate the use of the drugs in this protocol or place the subject at undue risk for treatment complications.