AR and ER Imaging in Metastatic Breast Cancer

Inclusion Criteria

• •1. Metastatic breast cancer, with at least one known metastasis outside of the liver
• •2. Presence of a lesion that is safely accessible for tumor biopsy (may be liver lesion)
• •3. Postmenopausal status defined as one of the following:
• •* age ≥60 years
• •* previous bilateral oophorectomy
• •* age \<60 years and amenorrhea for \>12 months in the absence of interfering hormonal therapies (such as LH-RH agonists and ER-antagonists)
• •* patients age \<60 years using an ER-antagonist should have amenorrhea for \> 12 months and FSH \>24 U/L and LH \>14 U/L e. patient age \<60 years using LH-RH agonists should continue LH-RH-agonists until after the PET procedures
• •4. Initially ER-positive tumor histology.
• •5. ECOG performance status 0-2.
• •6. Signed written informed consent
• •7. Able to comply with the protocol