Age

18–70

Sex

ALL

Healthy volunteers

Not accepted

Malignant hypertension
Average sitting systolic blood pressure≧180mmHg
Type 2 diabetes with hemoglobin A1c≥9%
Type 1 diabetes
New York Heart Association class Ⅱ-Ⅳ congestive heart-failure
Unstable angina
Second or third degree heart block or history of sick sinus syndrome unless a pacemaker was in place
Atrial fibrillation
Bradycardia (\<60 bpm, seated)
Asthma or other obstructive pulmonary disease
History of myocardial infarction
Stroke in the 6 months before screening
Known contraindications to β-adrenergic blocker therapy
Glutamic-oxaloacetic transaminase and/or glutamic-pyruvic transaminase\>3 times upper limit of normal
Crea\>2 times upper limit of normal
Pregnancy or lactation

A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Hypertension