Lead Sponsor

Ontario Clinical Oncology Group (OCOG)

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. T1/T2a N0 M0 NSCLC, either by: (a) histological confirmation (squamous cell, adenocarcinoma, large cell carcinoma, or not specified) and CT thorax and/or PET-CT evidence, or (b) a suspicious growing nodule on serial CT imaging, with malignant PET Fluorodeoxyglucose (FDG) avidity, for which a biopsy would be extremely risky.
•2. Deemed medically inoperable (as reviewed by a thoracic surgeon and defined as surgically resectable but, because of underlying physiological medical problems \[e.g. chronic obstructive pulmonary disease (COPD), heart disease\], surgery is contraindicated) or Radiotherapy is preferred by the patient due to high operable risk.

•1. Less than 18 years of age.
•2. Eastern Cooperative Oncology Group (ECOG) performance status 3 or higher.
•3. Prior invasive malignancy within the past 3 years (excluding non-melanomatous skin cancer).
•4. History of ataxia telangiectasia.
•5. Previous radiotherapy (RT) in the vicinity of the tumour, such that significant overlap could occur.
•6. Previous pneumonectomy with Stage I lung cancer in the remaining lung.
•7. Diagnosis of idiopathic pulmonary fibrosis and/or interstitial lung disease.
•8. Planned for other anticancer therapy (chemotherapy, biological targeted therapy).
•9. Female, who is currently pregnant or lactating.
•10. Geographic inaccessibility for follow-up.
•11. Unable to provide informed consent.

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