Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease

Inclusion Criteria

• •chronic obstructive pulmonary disease stage IV
• •indication for the use of a nocturnal non-invasive ventilation (according to the German guidelines Schoenhofer et al. 2008)
• •patient has not yet used non-invasive ventilation at all or inadequately (less than 3 hours per day)
• •chronic obstructive pulmonary disease stage IV (- healthy volunteers are also eligible for the sub-trial of this study to validate night movement accuracy of an activity monitor)