RSV F Dose-Ranging Study in Women

Exclusion Criteria

• •2. Willing and able to give informed consent prior to study enrollment.
• •3. Able to comply with study requirements.
• •4. Women who are not surgically sterile must have a negative urine pregnancy test prior to each vaccination; will be advised through the Informed Consent process to avoid becoming pregnant over the duration of the study, and must assert that they will employ an effective form of birth control for the duration of the study. Acceptable forms of birth control are: credible history of continuous abstinence from heterosexual activity, hormonal contraceptives (oral, injectable, implant, patch, ring), double-barrier contraceptives (condom or diaphragm, with spermicide), and IUD.
• •Subjects will be excluded if they fulfill any of the following criteria:
• •1. Participation in research involving investigational product (drug / biologic / device) within 45 days before planned date of first vaccination.
• •2. History of a serious reaction to any prior vaccination.
• •3. Received any vaccine in the 4 weeks preceding the study vaccination; or any RSV vaccine at any time.
• •4. Any known or suspected immunosuppressive condition, acquired or congenital, as determined by history and/or physical examination.
• •5. Chronic administration (defined as more than 14 continuous days) of immunosuppressants or other immune-modifying drugs within 6 months prior to the administration of the study vaccine. An immunosuppressant dose of glucocorticoid will be defined as a systemic dose ≥10mg of prednisone per day or equivalent. The use of topical, inhaled, and nasal glucocorticoids will be permitted.
• •6. Administration of immunoglobulins and/or any blood products within the 3 months preceding the administration of the study vaccine or during the study.
• •7. Donated blood within 3 weeks of the planned date of first vaccination.
• •8. Acute disease at the time of enrollment (defined as the presence of a moderate or severe illness with or without fever, or an oral temperature \>38.0°C on the planned day of vaccine administration).
• •9. Known disturbance of coagulation.
• •10. Women who are pregnant or breastfeeding, or plan to become pregnant during the study.
• •11. Suspicion or recent history (within one year of planned vaccination) of alcohol or other substance abuse.
• •12. Any condition that in the opinion of the Investigator would pose a health risk to the subject if enrolled or could interfere with evaluation of the vaccine or interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).