Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease

Exclusion Criteria

• •1. Acute Coronary Syndrome
• •2. Contraindication for administration of prasugrel or ticagrelor
• •1. Known hypersensitivity to clopidogrel or ticagrelor
• •2. Active bleeding (peptic ulcer, intracranial bleeding)
• •3. Severe liver impairment
• •4. Any previous history of intracranial bleeding or transient ischemic attack or ischemic cerebrovascular event
• •5. Treatment with potent CYP3A4 inhibitors (ketoconazole, clarithromycin, nefazodone, ritonavir, atazanavir)
• •3. Requirement for oral anticoagulant agents prior to the day 30 visit
• •4. History of gastrointestinal bleeding, genitourinary bleeding or other site abnormal bleeding within the previous 3 months
• •5. Increased risk for bradyarrhythmias, according to the investigator's evaluation
• •6. Severe non-controlled chronic obstructive pulmonary disease
• •7. Creatinine clearance \<30ml/min/1.73mm2
• •8. HbA1c \> 10mg/dl