About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Neuropeptides in Human Reproduction | Clinical Trials | Clareo Health

Back to clinical trial search

COMPLETEDPhase 1NCT01952782

Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid...

Lead sponsor: Massachusetts General Hospital•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Massachusetts General Hospital

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Ages 21-40 (healthy men and regularly cycling women) OR ages 18-75 (men and women with hypogonadotropic hypogonadism (HH))
•Normal blood pressure (systolic BP \<140 mm Hg, diastolic BP \<90 mm Hg)
•White blood cell, platelets, prolactin, and thyroid stimulating hormone (TSH)within 90%-110% of laboratory reference range
•Negative urine drug screen panel
•Hemoglobin:
•1. For healthy men and healthy regularly cycling women: normal
•2. For men and women with HH: No less than 0.5 gm/dL below the lower limit of the reference range for normal women
•Blood urea nitrogen (BUN), creatinine, liver function tests not elevated
•For healthy subjects: Normal reproductive function and history
•For healthy subjects: Body Mass Index (BMI) 18.5-30kg/m2
•For subjects with HH: All medical conditions stable and well controlled

Exclusion Criteria

•History of medication reaction requiring emergency medical attention
•Illicit drug use
•Consumption of more than 10 alcoholic drinks per week
•Difficulty with blood draws
•Currently seeking fertility, breastfeeding, or pregnant
•For healthy subjects: history of chronic disease and prescription medication use (with the exception of seasonal allergy medication)
•For subjects with HH: prescription medications known to affect reproductive endocrine function except for those used to treat the subject's reproductive condition

Related studies

The REgistry of Very Early Estrogen and AnovuLation

NCT06583408 · Hypothalamic Amenorrhea, Functional, Hypothalamic Amenorrhea, and more

Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate

NCT01601171 · Kallmann Syndrome, Hypogonadotropic Hypogonadism, and more

COMPLETEDPhase 3

A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)

NCT01709331 · Hypogonadism, Hypogonadotropic Hypogonadism

TERMINATEDPhase 4

A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial

NCT05205837 · Hypogonadism, Hypogonadism, Male, and more

COMPLETEDPhase 2

A 6 Month Safety Extension Study of MBGS205

NCT02908074 · Hypogonadotropic Hypogonadism

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 31, 2024Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment61

Start dateApr 2014

Last updatedJul 31, 2024

Condition

Hypogonadotropic Hypogonadism

Locations shown

Massachusetts General Hospital

Boston, Massachusetts

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 31, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions