Study on Reflex Response During Temporary Stimulation and Inhibition of Chemoreceptors of Carotid Bodies - a Pilot Study

Exclusion Criteria

• •bilateral significant carotid artery stenosis;
• •complete closure or critical constriction of either of the carotid arteries;
• •brain stroke or transient ischaemic attack (TIA) within 6 months prior to the inclusion in the study;
• •unstable angina pectoris, coronary attack within 3 months prior to the inclusion in the study;
• •coronary revascularisation or clinically significant infection within 1 month prior to the inclusion in the study;
• •significant chronic neurological condition in medical history;
• •dipyridamole or theophyline-based medications taken by the patient;
• •bronchial asthma;
• •GOLD 3 or 4 Chronic Obstructive Pulmonary Disease (COPD) in medical history;
• •second or third degree atrioventricular block, sick sinus syndrome, or an additional evident track of atrioventricular conducting;
• •advanced first degree atrioventricular block (PQ \> 240 ms)
• •extension of the QTc interval \> 0.5 s;
• •grade 3 (ESC) arterial hypertension;
• •previously stated oversensitivity to adenosine;
• •pregnancy;
• •patients undergoing haemodialysis or peritoneal dialysis at inclusion in the study;
• •undergone heart transplantation;
• •any significant, in the investigator's assessment, aberrations detected in additional tests, increasing the risk related to performing procedures predicted by the protocol;
• •lack of informed consent for the participation in the study;
• •stage III (Fontaine) obliterative arteriosclerosis of the lower limb and/or Buerger's disease.