Lead Sponsor

Hospital Universitario Dr. Jose E. Gonzalez

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•patients with a confirmed diagnosis of ALS according to El Escorial criteria. Diagnosis-time less than four years.
•Over 18 years old. Forced vital capacity ≥ 40%.
•One year of evolution.
•Adequate nutritional state

•Severe bulbar ALS involucre.
•Inadequate nutritional status.
•Spondylotic myelopathy, or abnormalities in imaging study.
•Having concomitant neurological or psychiatric disease.
•Systemic disease with poor-control.
•History of treatment with steroids or immunoglobulins in the last year.
•Participate in the past three months in a Clinical Trial.
•History of malignancy or cancer today.
•Intracranial hypertension.
•Clinical suggestive data of infection in the site of lumbar puncture.
•Tracheostomy.
•Use of mechanical ventilation. Forced vital capacity less than 40%. HIV-seropositive or presence of antibodies against hepatitis B or C in the serological studies.