Age

40–80

Sex

ALL

Healthy volunteers

Not accepted

A clinical diagnosis of moderate to severe COPD according to the following criteria:
* Current or ex-smokers with at least 10 pack-year smoking history
* Post-bronchodilator FEV1 \>/= 35% and \</= 80% of predicted normal value
* Post-bronchodilator FEV1/FVC (forced vital capacity) ratio \<0.70
* Post-bronchodilator improvement in FEV1 \>/= 100 mL

Current evidence or recent history of clinically significant or unstable disease (other than COPD)
Current diagnosis of asthma
Presence of history of clinically significant allergy requiring treatment
COPD exacerbation within 6 weeks
Use of daily oxygen therapy \> 10 hours
Thoracotomy with pulmonary resection
Use of systemic steroids within 3 months
Lower respiratory tract infection within 30 days
Upper respiratory tract infection within 30 days requiring treatment with antibiotics
History of tuberculosis, bronchiectasis, or other non-specific pulmonary disease
Prolonged corrected QT (QTc) interval \>450 msec males and \>470 msec females, or history of long QT syndrome

A Safety, Pharmacokinetic and Pharmacodynamic Study of PUR0200 in COPD Patients