Lead Sponsor

Shahid Beheshti University of Medical Sciences

Age

50 - 80 years

Sex

MALE

Healthy Volunteers

No

•1. Histologically confirmed adenocarcinoma of the prostate
•2. Age range of 50-80
•3. ECOG performance status 0-1
•4. Life expectancy \> 5 years
•5. Must be enrolled in a social security program
•6. No other cancer, except basal cell skin cancer, that has been treated or relapsed within the past 5 years
•7. No severe uncontrolled hypertension (systolic BP ≥ 160 mm Hg or diastolic BP ≥ 90 mm Hg)
•8. No contraindication to luteinizing hormone-releasing hormone agonists
•9. No contraindication to pelvic irradiation (e.g., scleroderma, chronic inflammatory gastrointestinal disease)
•10. No hip prosthesis
•11. Must not be deprived of liberty or under guardianship
•12. No geographical, social, or psychological reasons that would preclude follow up

•1. Clinical stage T3 or T4
•2. Gleason score ≥ 8
•3. Serum PSA ≥ 20 ng/mL and ≤ 100 ng/mL
•4. other prior surgery for prostate cancer
•5. concurrent participation in another clinical trial which would require approval upon entry to this trial
•6. Gastrointestinal disorders such as IBD, reflux and peptic ulcers
•7. Any adverse reaction to curcumin