Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients

Exclusion Criteria

• •Shock status requiring vasopressor
• •Active infection, for example Spontaneous bacterial peritonitis
• •Acute renal failure patients of any cause
• •Clinically relevant coronary artery disease(NYHA functional angina classification III/IV),congestive heart failure NYHA III/IV), clinically relevant cardiomyopathy, history of myocardial infarction in the past 12 months
• •Poorly controlled hypertension (BP 150/100mmHg)
• •Hepatocellular carcinoma
• •History of another primary malignancy ≤ 3years
• •Medical or psychological conditions that would not permit the subject to complete thte study or sign informed consent
• •Pregnancy or lactation period
• •Serum creatinine ≧ 6mg/dL
• •Involvement in the conduct of other study within 30 days
• •Known hypersensitivity to Rifaximin or propranolol
• •Dysarrhythmia, inappropriate for study on investigator's judgment