A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma

Exclusion Criteria

• •1. Patients with known liver metastases
• •2. Radiation, chemotherapy, immunotherapy, any other systemic anticancer therapy or participation in an investigational anti-cancer study ≤ 3 weeks prior to initiation of therapy
• •3. Patients with known brain metastasis
• •4. Patients with any gastrointestinal dysfunctions that could interfere with the interpretation of the food effect data
• •5. Patients with known intolerance to low or high fat meals
• •6. In the opinion of the investigator, patients who are significantly below their ideal body weight