To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection

Exclusion Criteria

• •Any contraindication to MRI (pregnancy, metallic fragments in the eyes, vascular clips, Pacemakers etc)
• •History of knee replacement
• •Known sensitivity or allergy to any component of Euflexxa
• •Inflammatory arthritis
• •Previously received viscosupplementation therapy within 6 months of study enrollment
• •Intra-articular injection of corticosteroid to study joint within the past 3 months
• •Arthroscopic or open surgery within the previous 12 months or planned surgery to the study joint
• •Concomitant medications of oral/parenteral corticosteroids
• •Morbid obesity defined as body mass index (BMI) \>40 kg/m2
• •Active malignancy; an active systemic infection; recent high impact or high energy trauma (clinically defined) to the study joint
• •Large knee effusion based on clinical exam or imaging