Lead Sponsor

University of Florida

Collaborators

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

No

•Gestational age ≥ 35 weeks gestation
•Age of life ≤ 48 hours
•Diagnosis of hypoxic respiratory failure (HRF) as defined by a post-ductal SaO2 ≤90% in ≥50% oxygen with a PEEP of ≥ 6cm or an oxygenation index (OI) ≥ 10 but ≤ 15 when mean airway pressure and PaO2 are known.
•Mothers (ages 18 - 65) of eligible subjects for additional data collection

•Gestational age \< 35 weeks gestation.
•Post-natal age \> 48 hours.
•Previous treatment with 100% oxygen for longer than 4 hours.
•Confirmed congenital diaphragmatic hernia.
•Suspected or confirmed congenital airway or pulmonary anomaly.
•Suspected or confirmed chromosomal anomaly or genetic aberration, with the exception of patients with trisomy 21 who do not have complex congenital heart disease.
•Infants with pneumothorax as the primary cause of their HRF.
•Infants with confirmed complex congenital heart disease.