Aldosterone Antagonism and Microvascular Function

Exclusion Criteria

• •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, congestive heart failure, cardiac shunts, cardiac surgery, pulmonary hypertension, cardiac arrhythmias, family history of cardiac arrhythmias or sudden cardiac death)
• •Diabetes mellitus/impaired glucose metabolism (fasting glucose values \> 5.6 mmol/L)
• •Grade 2 or 3 hypertension (office blood pressure: \> 160/100 mm Hg; ABPM \> 150/90 mm Hg)
• •Unstable or severe pulmonary disease
• •Unstable or severe thyroid disorders
• •Inflammatory diseases
• •Alcohol use \> 2 U/day (women)/\> 3 U/day (men)
• •Use of antihypertensive, lipid-lowering or glucose-lowering medications,
• •Use of corticosteroids, medication known to inhibit or induce CYP3A4, lithium, and tricyclic antidepressants or antipsychotic medication, and regular use (weekly or several times a week) of NSAIDs
• •Plasma potassium levels \< 3.2 mmol/L or \> 5 mmol/L
• •eGFR \< 60 mL/min
• •Impairment of hepatic function
• •Pregnancy or lactation