Grade 2 or 3 hypertension (office blood pressure: \> 160/100 mm Hg; ABPM \> 150/90 mm Hg)
Unstable or severe pulmonary disease
Unstable or severe thyroid disorders
Inflammatory diseases
Alcohol use \> 2 U/day (women)/\> 3 U/day (men)
Use of antihypertensive, lipid-lowering or glucose-lowering medications,
Use of corticosteroids, medication known to inhibit or induce CYP3A4, lithium, and tricyclic antidepressants or antipsychotic medication, and regular use (weekly or several times a week) of NSAIDs
Plasma potassium levels \< 3.2 mmol/L or \> 5 mmol/L
eGFR \< 60 mL/min
Impairment of hepatic function
Pregnancy or lactation
Clareo Health | Aldosterone Antagonism and Microvascular Function
