Care Path for the Management of Ulcerative Colitis

Inclusion Criteria

• •Females of child bearing potential must have a negative serum pregnancy test prior to randomization, and must use a hormonal (oral, implantable or injectable) or barrier method of birth control throughout the study. Females unable to bear children must have documentation of such in the source records -- - Documented diagnosis of UC with a Mayo Clinic Score (MCS) ≥6 and a baseline Mayo Endoscopy Score \>2.
• •Either an elevated serum C-reactive protein (CRP) (above the Upper Level of Normal (ULN) according to local laboratory results) or elevated fecal calprotectin (\> 250 mg/kg) concentration.
• •Requires sigmoidoscopic evaluation at baseline (standard of care)
• •Written informed consent must be obtained and documented.
• •Ability of subject to participate fully in all aspects of this clinical trial in the opinion of the investigator.