Phase II Study of Maintenance Capecitabine to Treat Resectable Colorectal Cancer

OBJECTIVES Primary evaluate the disease free survival rate of three years in patients with stage IIIC or resectable stage IV colorectal cancer treated with maintenance capecitabine. Secondary 1. Evaluate the over all survival time in patients treated with these regimens. 2. Correlate genetic patterns and the presence or absence of specific tissue biomarkers with response and prognosis in patients treated with these regimens. 3. Determine quality of life (QOL) of patients treated with maintenance capecitabine versus chemotherapy termination. 4. Determine the toxic effects of maintenance regimens in these patients. 5. Determine the convenience of care in patients treated with maintenance regimens. OUTLINE: This is a single arm, single-enter study. Patients are receiving therapies as below. Patients undergo R0-R1 resection and receive adjuvant chemotherapy oxaliplatin with fluorouracil (5FU) and folinic acid（FOLFOX）or oxaliplatin with oxaliplatin with capecitabine(capox) for no less than 4 months. Radiotherapy may be applied for patients with rectal cancer if clinicians suspect that is necessary. Then patients receive oral capecitabine for 12 months maintenance. Quality of life is assessed at completion of adjuvant treatment, at completion of maintenance chemotherapy , and at 1 year after maintenance chemotherapy. After completion of adjuvant treatment, patients are followed every 3 months for 2 years, and then every 6 months for 3years. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study within 3 years. Eligibility Ages Eligible for Study: 18-80 Years old Genders Eligible for Study: Both Accepts Healthy Volunteers: No