Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Rush University Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age greater than 18 years old.
SAH due to aneurysm, as determined by CT angiogram or cerebral angiogram.
Modified Fisher (mF) grade 3 or 4 SAH, defined as thick cisternal blood without (grade 3) or with (grade 4) intraventrciular blood.
Exclusion of the aneurysm from the parent circulation by endovascular embolization (Raymond class I or II) within 48 hours of ictus.
Ventriculostomy placement must occur prior to randomization.
Informed consent obtained from the patient or patient's decision maker
You may not be if
Determination by treating physician(s) that no ventriculostomy is needed.
Presence of intrinsic clotting disorders (e.g. due to hepatic failure, nephrotic syndrome, etc). Subjects whose pharmacologic anticoagulation is reversed, as determined by PT/INR, PTT within our institution's normal range, will be permitted to participate in this study.
Presence of significant anemia, defined as hemoglobin \< 8 gm/dL.
Patients who undergo endovascular techniques requiring post-operative dual anti-platelet therapy.
Residual aneurysm sac filling (Raymond class III occlusion).
Aneurysm or vessel perforation during the endovascular procedure.
Presence of craniectomy.
Significant neurologic disability prior to the onset of SAH.
Determination that administration of tPA/placebo cannot be initiated within 72 hours of symptom onset.
Presence of untreated intracranial aneurysms larger than 3mm on CT angiography or cerebral angiogram.
