Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness

Exclusion Criteria

• •For all individuals:
• •History of neurologic disorder or systemic medical condition that may interfere with central nervous system function
• •History of seizures
• •History of heard injury with loss of consciousness or concussion
• •Positive screen for drugs of abuse: cocaine, marijuana, phencyclidine, ketamine, opioid, or other agent that is being abused in the opinion of the investigator
• •Females who are currently pregnant or plan to become pregnant during the study period
• •History of allergy, sensitivity, or intolerance to N-methyl-D-Aspartate receptor (NMDAR) ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone
• •History of any ferromagnetic object in the body
• •Presence of any medical device or implant for which MRI is contraindicated including cardiac pacemaker, aneurysm clip, cochlear implant, copper intrauterine device (IUD), neurostimulator, or any other device deemed unsafe
• •Bullet or shrapnel in body
• •Metallic braces or permanent retainer
• •Significant claustrophobia
• •For Healthy Individuals
• •Personal history of any Axis I disorder according to the Structured Clinical Interview for the DSM-5 (SCID-5) criteria
• •History of treatment with antidepressant, antipsychotic, stimulant,sedative/ hypnotic, mood stabilizing, or anticholinergic medications or lithium
• •History among first-degree family members of any psychotic illness or major mood disorder (e.g., major depressive disorder, recurrent; bipolar I or II disorder)
• •For Patients
• •Treatment with Clozaril
• •Change in medication within 1 month
• •Hospitalization within 1 month