Safety and Immunogenicity of Live Attenuated Influenza H5N2

Exclusion Criteria

• •Known history of egg allergy
• •Having had recently influenza infection confirmed as H5
• •History of bronchial asthma
• •History of chronic lung diseases
• •History of chronic rhinitis
• •History of immunodeficiency state
• •History of immunosuppression
• •History of heavy smoking (more than 5 rolls per day)
• •History of alcoholic (pure drink 200 ml per day)
• •Acute infectious and noninfectious diseases (within 2 weeks)
• •Exacerbation of chronic diseases or cancer or HIV positives
• •Anamnestic leukocytosis, hepatitis B and C positives
• •The volunteers who have been taking immunoglobulin products or have had a blood transfusion during past three months before the beginning of the experiment
• •Participation in other research study or stop participant less than 1 month
• •Pregnancy or plan to become pregnant for 60 days after enrollment or breast feeding
• •Any concomitant medication with Aspirin
• •Poultry workers