Impact of a Dolutegravir-based Regimen on Early Mortality of AIDS Patients

Inclusion Criteria

• •Patients with confirmed HIV-1 infection (positive Western blot or plasma HIV-1 RNA \>1,000 copies/ml)
• •No previous use of any ARV drug (drug-naïve patients)
• •Presence of clinical symptoms according to Rio de Janeiro / Caracas´ AIDS definition (Asthenia, Cachexia/Wasting, Cough, Dermatitis, persistent, Diarrhea, Fever, Lymphadenopathy, Candidiasis, oral, or hairy leukoplasia, Central nervous system dysfunction, Herpes zoster in individual younger than 60 years of age)), and/or any active AIDS-defining condition
• •Baseline CD4+ cells count equal or lower than 50 cells/mm3
• •Age equal or higher than 18 years
• •HIV-1 plasma viral load ≥ 1,000 copies of HIV-1 RNA/ml